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KMID : 0615720150320020187
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 2 p.187 ~ p.195
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The Effect of Poria Cocos Pharmacopuncture at SP6(Sameumgyo) and ST36(Joksamni) on Chronic Stress Model(CSM) Rats
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Kim Seon-Wook
Kim Jae-Hong
Cho Myoung-Rae
Shin Jeong-Cheol
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Abstract
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Objectives: The purpose of this study is evaluating the effect of Poria cocos pharmacopuncture (PCP) at SP6(Sameumgyo) and ST36(Joksamni) on chronic stress model(CSM) rats.
Methods: The experimental rats were assigned to five groups: normal, CSM(control), PCP1X, PCP2.5X and PCP5X. The experimental rats in CSM(control), PCP1X, PCP2.5X and PCP5X were put through a timetable to cause CSM. PCP(20 μl) was administered at SP6, ST36 to groups PCP1X, PCP2.5X and PCP5X once every three days for a total of six times. The weight of the rats was measured by an electronic scale after PCP injection, once every three days for a total of six times. Blood samples were taken from the rats for analysis of aspartate aminotransferase(AST) and alanine aminotransferase(ALT). Serotonin and norepinephrine were measured by enzyme-linked immunosorbent assay(ELISA) kit.
Results: The experimental groups(PCP1X, 2.5X, 5X) showed significant body weight increase compared to the control group. Regarding AST and ALT changes in serum, the experimental groups(PCP2.5X, 5X) showed a significant decrease compared to the control group. For Serotonin changes in serum, the experimental group(PCP5X) showed a significant increase compared to the control group. For Norepinephrine changes in serum, the experimental groups(PCP2.5X) showed a significant decrease compared to the control group.
Conclusions: These data suggest that PCP at SP6, ST36 has therapeutic effects on CSM rats.
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KEYWORD
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Chronic stress model, Poria cocos, Pharmacopuncture, SP6(Sameumgyo), ST36(Joksamni)
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